Garfield of Dreams: Seth MacFarlane tries to get Hollywood to care about has-been cartoons again.
I Hate My Teenage Mutant Ninja Turtles: A mother realizes her sons have become something she always hated: ninja turtles!
- MAD News - The MAD News anchor announces that March's Madness becomes March's Sadness. (Animated by Mark Marek)
- Opening Scene
- Garfield of Dreams (Comic Parody of Garfield / Movie Parody of Field of Dreams)
- Animated Marginals segment - Alfred E. Neuman juggles, then a bunch of balls fall on him.
- Bobo the Clown marries balloon instead of Dorine (Animated by Mike Wartella)
- What's Wrong with this Picture?: Jay-Z
- The Left Hand of Doom (Comic Parody of Hellboy) (Ad Parodies segment) (Animated by Nate Theis)
- Dr. Glass Johnson Makes the Score (Cartoon)
- Duck Takes a Bath with His Rubber Boy (Animated by Don Martin)
- Stapler Goes to Dentist (Cartoon)
- Lancing with the Stars (TV Parody of ABC's Dancing with the Stars) (Ad Parodies segment)
- Robots Build a Human (Stop-motion Cartoon segment)
- Thor hammers bolts with his own hammer (Spoof on ) (Animated by Mike Wartella)
- Spy vs. Spy - Swing Tree (Spy vs. Spy segment)
- Animated Marginals segment - A guy is too afraid to go on diving board, then falls down on stairs.
- Wizard or Crazy Person (Cartoon)
- I Hate My Teenage Mutant Ninja Turtles (TV Parody of I Hate My Teenage Daughter and Teenage Mutant Ninja Turtles)
- 5-second Cartoon - (from Lancing with the Stars) Buzz Aldrin says, "I wonder if Bristol Palin had to go through this." (5-second Cartoon segment)
- This is the second time I Hate My Teenage Daughter showed up, the second time Mr. & Mrs. Smith appeared, and the second appearance of the What's Wrong with this Picture? segment.
- This is the third appearance of Garfield, and the third time Spy vs. Spy was lineless.
- This is the fourth time a Mike Wartella segment appeared before Spy vs. Spy. The previous ones were:
- Frank Welker, the current voice of Garfield, reprises his role.
- Michael Sinterniklaas reprises as the voice of Leonardo from the TMNT 2003 TV series.
- Tara Strong gave a little nod to Chowder and the Fairly OddParents by using her "Truffles" and "Timmy Turner" voices in the episode.
- Frank Welker reprises his role as Garfield.
- Kevin Shinick reprises his role as Brad Pitt (but as Fred Zombie) from The Walking Fred.
- Hugh Davidson - Doonesbury, Peter Jackson, Michelangelo, Construction Worker, B.C., Prime Minister, and Buzz Aldrin
- Dan Milano - Dagwood Bumstead, Raphael, and Dad
- Rachel Ramras - Drew Barrymore, Angelina Jolie, Nikki Miller, Edna, Lancing with the Stars Announcer, Doris, and Dennis the Menace
- Kevin Shinick - Seth MacFarlane, Will Smith, Brad Pitt, The Shredder, Thor, Bobo, Dick Tracy, What's Wrong With This Picture? Announcer, the Wizard of Id, and the MAD News Anchor
- Michael Sinterniklaas - Leonardo, Tom Cruise, and Steven Spielberg
- Tara Strong - Loretta Lockhorn, Annie Watson, and Boy with Scissors
- Fred Tatasciore - Hagar the Horrible, Hellboy, and Wizard or Crazy Person Announcer
- Frank Welker - Garfield, Basketball Announcer, and Donatello